Negative regulation of muscle hypertrophy

Across TCGA patient cohorts, RNA activity of the Negative regulation of muscle hypertrophy pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TP53BP1_S999, VIM_S72, and DAB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle hypertrophy activity versus TP53BP1_S999 in LSCC (Pearson r = -0.54).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TP53BP1_S999 →	-0.848	-0.067	<.001	.002	3	5
BRCA	VIM_S72 →	+0.704	+0.048	<.001	<.001	3	5
BRCA	DAB2 →	+0.306	+0.032	<.001	<.001	3	5
BRCA	DAB2_S723 →	+0.517	+0.035	<.001	<.001	3	5
GBM	SAP30BP →	-0.281	-0.058	<.001	<.001	3	5
LSCC	DOCK10_T1440 →	+0.553	+0.051	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014741 vs TP53BP1_S999 — LSCC

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