Negative regulation of muscle hypertrophy

Across TCGA cell cohorts, RNA activity of the Negative regulation of muscle hypertrophy pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are G6PD, TRIM16L, and OSGIN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of muscle hypertrophy activity versus G6PD in LIVER (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	G6PD →	+3.532	+0.467	<.001	<.001	3	8
LIVER	TRIM16L →	+4.650	+0.454	<.001	<.001	3	6
LUNG_NSCLC_LUAD	OSGIN1 →	+1.229	+0.151	.004	.005	3	6
LUNG_NSCLC_LUAD	AKR1C1 →	+3.703	+0.214	<.001	<.001	3	6
LUNG_SCLC	ACVR2B →	-0.827	-0.302	.007	.009	3	6
LUNG_NSCLC_LUAD	AKR1C3 →	+3.545	+0.197	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014741 vs G6PD — LIVER

Explore this scatter interactively →