Regulation of skeletal muscle contraction by calcium ion signaling

Across TCGA patient cohorts, RNA activity of the Regulation of skeletal muscle contraction by calcium ion signaling pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TTC7B, DMD, and DAG1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle contraction by calcium ion signaling activity versus TTC7B in UCEC (Pearson r = 0.48).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TTC7B →	+0.393	+0.084	<.001	<.001	3	8
HNSC	DMD →	+0.983	+0.144	<.001	<.001	3	8
HNSC	DAG1 →	+0.704	+0.163	<.001	<.001	3	7
GBM	SBF2 →	+0.332	+0.099	<.001	<.001	3	7
OV	TNS2_S102 →	+0.863	+0.037	<.001	.005	3	7
UCEC	MYLK →	+1.022	+0.079	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014722 vs TTC7B — UCEC

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