Regulation of skeletal muscle contraction by calcium ion signaling

Across TCGA cell cohorts, RNA activity of the Regulation of skeletal muscle contraction by calcium ion signaling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYCARD, SLC7A1, and C18orf32, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PYCARD grouped by Regulation of skeletal muscle contraction by calcium ion signaling-low versus -high activity in BLOOD_Lymphoma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PYCARD →	+4.117	+1.805	.004	<.001	3	4
SKIN	SLC7A1 →	-0.737	-0.839	<.001	.002	3	4
LARGE_INTESTINE	C18orf32 →	+0.948	+1.396	.001	<.001	3	4
LUNG_NSCLC_LUAD	C1orf109 →	-0.694	-0.836	.002	<.001	3	3
BLOOD_Myeloma	NEMP2 →	-0.717	-1.381	.007	<.001	3	3
BLOOD_Leukemia	TRIP10 →	-1.246	-1.125	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PYCARD by Regulation of skeletal muscle contraction by calcium ion signaling activity — BLOOD_Lymphoma

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