Regulation of skeletal muscle contraction by calcium ion signaling

Across TCGA cell cohorts, RNA activity of the Regulation of skeletal muscle contraction by calcium ion signaling pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NME1, POLR2E, and ARID4A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of skeletal muscle contraction by calcium ion signaling activity versus NME1 in CNS (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	NME1 →	+0.815	+1.042	.001	.008	3	4
CNS	POLR2E →	+0.744	+0.984	.001	.006	3	4
CNS	ARID4A →	-0.474	-0.759	.001	.005	3	3
BLOOD_Leukemia	MAN2C1 →	-0.847	-0.276	.003	.002	1	5
LIVER	C3orf14 →	+4.166	+0.354	<.001	.009	3	3
LUNG_NSCLC_LUAD	PWP1 →	+0.708	+1.032	.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014722 vs NME1 — CNS

Explore this scatter interactively →