Striated muscle tissue development

Across TCGA cell cohorts, RNA activity of the Striated muscle tissue development pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP3CA, LGALS3, and ENTR1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Striated muscle tissue development activity versus PPP3CA in OVARY (Pearson r = 0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PPP3CA →	+1.258	+0.231	.004	.009	3	7
CNS	LGALS3 →	+2.172	+0.206	.007	.001	3	5
OESOPHAGUS	ENTR1 →	-0.964	-0.218	.002	.001	3	5
CNS	TWNK →	-0.957	-0.225	.003	.003	3	5
CNS	XPO5 →	-0.352	-0.179	.008	<.001	3	5
LUNG_SCLC	RRP12 →	-0.732	-0.226	.002	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014706 vs PPP3CA — OVARY

Explore this scatter interactively →