Response to purine-containing compound

Across TCGA patient cohorts, RNA activity of the Response to purine-containing compound pathway is significantly associated with the RNA expression of multiple genes, with the ACC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFAIP3, SAMD4A, and FOS, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to purine-containing compound activity versus TNFAIP3 in ACC (Pearson r = 0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ACC	TNFAIP3 →	+2.265	+0.028	<.001	<.001	3	29
THYM	SAMD4A →	+1.599	+0.027	<.001	<.001	3	28
THYM	FOS →	+2.010	+0.020	<.001	<.001	3	26
MESO	PTGS2 →	+1.793	+0.020	<.001	<.001	2	27
DLBC	NFKBIZ →	+1.815	+0.020	<.001	.003	3	26
PCPG	TMEM30BP1 →	+0.663	+0.010	<.001	.004	3	26

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014074 vs TNFAIP3 — ACC

Explore this scatter interactively →