Response to purine-containing compound

Across TCGA patient cohorts, RNA activity of the Response to purine-containing compound pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPING1, SF3B3, and NID2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to purine-containing compound activity versus SERPING1 in BRCA (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SERPING1 →	+0.607	+0.019	<.001	<.001	3	9
OV	SF3B3 →	-0.254	-0.033	<.001	.001	3	9
UCEC	NID2 →	+0.533	+0.036	.002	<.001	3	9
OV	SNRPD2 →	-0.443	-0.041	<.001	<.001	3	9
GBM	THRAP3 →	-0.243	-0.056	<.001	<.001	3	9
GBM	BCLAF1 →	-0.297	-0.056	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014074 vs SERPING1 — BRCA

Explore this scatter interactively →