Response to purine-containing compound

Across TCGA cell cohorts, RNA activity of the Response to purine-containing compound pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MARCKSL1, CBX2, and THAP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MARCKSL1 grouped by Response to purine-containing compound-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	MARCKSL1 →	-1.464	-0.131	.001	.003	3	4
OESOPHAGUS	CBX2 →	-1.662	-0.171	.002	.005	3	4
SOFT_TISSUE	THAP4 →	-0.573	-0.168	.003	.007	3	4
LUNG_NSCLC_LUAD	FBRSL1 →	-0.780	-0.136	.001	.001	3	3
LUNG_NSCLC_LUAD	C1orf109 →	-0.639	-0.138	.005	.005	3	3
LUNG_NSCLC_LUAD	HNRNPA1 →	-0.567	-0.152	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MARCKSL1 by Response to purine-containing compound activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →