Response to purine-containing compound

Across TCGA cell cohorts, RNA activity of the Response to purine-containing compound pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LDHB, VCP, and NSUN2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to purine-containing compound activity versus LDHB in OVARY (Pearson r = -0.39).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LDHB →	-0.915	-0.126	.001	.005	3	5
OVARY	VCP →	-0.608	-0.117	.009	.006	3	5
PANCREAS	NSUN2 →	-0.864	-0.206	.001	.001	3	5
URINARY_TRACT	WAPL →	-0.600	-0.319	.004	<.001	3	4
URINARY_TRACT	CTSA →	-0.767	-0.278	.006	.005	3	4
BONE	APEX2 →	-0.884	-0.197	<.001	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014074 vs LDHB — OVARY

Explore this scatter interactively →