Response to isoquinoline alkaloid

Across TCGA patient cohorts, RNA activity of the Response to isoquinoline alkaloid pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R1B, ACTR1B, and CCNE1_S103, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to isoquinoline alkaloid activity versus PPP1R1B in UCEC (Pearson r = -0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP1R1B →	+1.281	+0.096	<.001	.001	3	7
CCRCC	ACTR1B →	+0.232	+0.062	<.001	<.001	3	6
BRCA	CCNE1_S103 →	-1.000	-0.077	<.001	<.001	3	6
LSCC	CSE1L →	-0.312	-0.076	.001	.001	3	6
GBM	AK1 →	+0.463	+0.083	<.001	.001	3	6
LUAD	MCM5 →	-0.498	-0.071	.002	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014072 vs PPP1R1B — UCEC

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