Regulation of serotonin secretion

Across TCGA patient cohorts, RNA activity of the Regulation of serotonin secretion pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NDRG1, AOAH, and SERPING1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of serotonin secretion activity versus NDRG1 in LUAD (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	NDRG1 →	-1.171	-0.209	<.001	<.001	3	3
LUAD	AOAH →	+0.869	+0.141	<.001	.008	3	3
LUAD	SERPING1 →	+0.864	+0.123	<.001	.002	3	3
LUAD	KLHL6 →	+0.848	+0.116	<.001	.005	3	3
LUAD	IGHA2 →	+1.451	+0.144	<.001	<.001	3	3
LUAD	IGHA1 →	+1.916	+0.167	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014062 vs NDRG1 — LUAD

Explore this scatter interactively →