Regulation of norepinephrine secretion

Across TCGA patient cohorts, RNA activity of the Regulation of norepinephrine secretion pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIPA1L2_S1461, NIBAN2_S681, and MAST3_S847, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of norepinephrine secretion activity versus SIPA1L2_S1461 in GBM (Pearson r = 0.18).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SIPA1L2_S1461 →	+0.369	+0.109	<.001	<.001	3	5
GBM	NIBAN2_S681 →	+0.393	+0.078	.001	.004	3	5
OV	MAST3_S847 →	-1.032	-0.077	<.001	.003	3	4
UCEC	TNKS1BP1_S712 →	+0.726	+0.320	.001	.006	3	4
UCEC	BPTF →	-0.212	-0.418	.005	.008	3	4
UCEC	ANXA1 →	+0.514	+0.321	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014061 vs SIPA1L2_S1461 — GBM

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