Regulation of norepinephrine secretion

Across TCGA patient cohorts, RNA activity of the Regulation of norepinephrine secretion pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF1A, TRHR, and RPL36AP48, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of norepinephrine secretion activity versus KIF1A in GBM (Pearson r = 0.40).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KIF1A →	+0.910	+0.436	.002	<.001	3	4
LSCC	TRHR →	-0.401	-0.450	.005	.002	3	3
LSCC	RPL36AP48 →	-0.342	-0.391	.007	.002	3	3
BRCA	ZC3H12A →	-1.188	-0.400	.005	.006	3	3
GBM	LINC01289 →	+0.109	+0.433	<.001	<.001	3	3
OV	DUSP10 →	-1.004	-0.736	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014061 vs KIF1A — GBM

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