Regulation of epinephrine secretion

Across TCGA cell cohorts, RNA activity of the Regulation of epinephrine secretion pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLLP, R3HDM2, and GBGT1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLLP grouped by Regulation of epinephrine secretion-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PLLP →	+1.659	+1.036	.001	<.001	3	4
BLOOD_Leukemia	R3HDM2 →	+1.023	+1.545	.002	<.001	3	4
BREAST	GBGT1 →	+1.327	+0.569	<.001	.006	3	3
URINARY_TRACT	YIPF3 →	+0.672	+1.719	.005	<.001	3	3
URINARY_TRACT	LARGE2 →	+2.554	+1.554	<.001	<.001	3	3
URINARY_TRACT	STARD10 →	+3.219	+2.023	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLLP by Regulation of epinephrine secretion activity — LARGE_INTESTINE

Explore this box plot interactively →