Regulation of gamma-aminobutyric acid secretion

Across TCGA patient cohorts, RNA activity of the Regulation of gamma-aminobutyric acid secretion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ICAM1, POP1, and DPYSL2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of gamma-aminobutyric acid secretion activity versus ICAM1 in BRCA (Pearson r = -0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ICAM1 →	-0.697	-0.069	<.001	.002	3	5
BRCA	POP1 →	-0.362	-0.058	<.001	<.001	3	5
GBM	DPYSL2 →	+0.244	+0.099	.002	.003	2	6
CCRCC	NOB1 →	-0.280	-0.043	.001	.005	3	5
BRCA	RRP1 →	-0.287	-0.046	.001	<.001	3	5
GBM	TOP1_S394 →	-0.527	-0.160	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014052 vs ICAM1 — BRCA

Explore this scatter interactively →