Positive regulation of glutamate secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of glutamate secretion pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RBMS3, MANSC1, and DARS1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RBMS3 grouped by Positive regulation of glutamate secretion-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RBMS3 →	+1.053	+1.029	.005	.003	3	4
URINARY_TRACT	MANSC1 →	+2.087	+1.793	.009	<.001	3	4
BLOOD_Myeloma	DARS1 →	+0.545	+1.277	.005	<.001	3	3
BLOOD_Myeloma	SP100 →	+0.958	+1.536	<.001	.002	3	3
KIDNEY	PIEZO1 →	-0.785	-1.136	.003	.005	3	3
OESOPHAGUS	MRNIP →	-0.922	-1.213	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RBMS3 by Positive regulation of glutamate secretion activity — SKIN

Explore this box plot interactively →