Positive regulation of glutamate secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of glutamate secretion pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H2AC15, KCTD4, and TMX2-CTNND1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, H2AC15 grouped by Positive regulation of glutamate secretion-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	H2AC15 →	-0.656	-1.780	.002	<.001	3	2
BONE	KCTD4 →	+0.270	+1.929	.006	<.001	3	2
BONE	TMX2-CTNND1 →	-0.243	-1.929	.003	<.001	3	2
BONE	U2AF2 →	-0.216	-1.929	.005	<.001	3	2
SKIN	DPYSL2 →	-0.278	-1.021	<.001	.005	3	2
LARGE_INTESTINE	SHCBP1 →	-0.332	-1.118	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

H2AC15 by Positive regulation of glutamate secretion activity — SKIN

Explore this box plot interactively →