Positive regulation of glutamate secretion

Across TCGA cell cohorts, RNA activity of the Positive regulation of glutamate secretion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYFIP2, GMCL1, and SULT1A1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of glutamate secretion activity versus CYFIP2 in BLOOD_Leukemia (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CYFIP2 →	-2.796	-1.051	.002	<.001	3	3
BLOOD_Leukemia	GMCL1 →	-0.648	-0.907	.003	.002	3	3
BONE	SULT1A1 →	-3.120	-1.963	.002	.003	3	3
BLOOD_Myeloma	INTS9 →	+0.943	+0.238	<.001	.001	3	3
SOFT_TISSUE	ZNF697 →	+1.515	+1.934	.004	<.001	3	3
SKIN	MTMR3 →	+0.771	+1.237	.004	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014049 vs CYFIP2 — BLOOD_Leukemia

Explore this scatter interactively →