Regulation of glutamate secretion

Across TCGA patient cohorts, RNA activity of the Regulation of glutamate secretion pathway is significantly associated with the RNA expression of multiple genes, with the UVM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNCA, STXBP1, and P2RX7, each associated with the pathway in up to 23 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glutamate secretion activity versus SNCA in UVM (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	SNCA →	+1.498	+0.063	<.001	<.001	3	23
SCLC	STXBP1 →	+0.958	+0.136	<.001	<.001	3	21
ACC	P2RX7 →	+1.090	+0.070	<.001	<.001	3	16
DLBC	SGTB →	+0.897	+0.039	.001	.001	2	17
SARC	GABBR1 →	+1.074	+0.050	<.001	<.001	3	16
TGCT	SLC25A10 →	-0.652	-0.045	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014048 vs SNCA — UVM

Explore this scatter interactively →