Regulation of glutamate secretion

Across TCGA patient cohorts, RNA activity of the Regulation of glutamate secretion pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STXBP1, WDR44, and RBM14, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glutamate secretion activity versus STXBP1 in UCEC (Pearson r = 0.49).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STXBP1 →	+0.801	+0.082	<.001	<.001	3	6
GBM	WDR44 →	+0.192	+0.057	.002	.002	3	6
PDAC	RBM14 →	-0.214	-0.037	.005	.005	3	6
UCEC	SETD7 →	+0.384	+0.058	<.001	<.001	3	6
HNSC	RHOG →	+0.276	+0.048	<.001	.001	3	6
UCEC	DAPK3 →	+0.455	+0.064	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014048 vs STXBP1 — UCEC

Explore this scatter interactively →