Regulation of glutamate secretion

Across TCGA patient cohorts, RNA activity of the Regulation of glutamate secretion pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NCAPG, NUF2, and NME1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glutamate secretion activity versus NCAPG in UCEC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NCAPG →	-0.659	-0.449	.001	.001	3	7
LUAD	NUF2 →	-0.735	-0.292	.003	.003	3	7
CCRCC	NME1 →	-0.240	-0.302	.009	.006	3	7
COAD	ZCCHC24 →	+0.468	+0.583	.007	.001	3	7
UCEC	PTTG1 →	-0.767	-0.491	.001	<.001	3	7
UCEC	TTK →	-0.997	-0.491	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014048 vs NCAPG — UCEC

Explore this scatter interactively →