Regulation of glutamate secretion

Across TCGA cell cohorts, RNA activity of the Regulation of glutamate secretion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are INTS9, DNAJC24, and SEPTIN9, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of glutamate secretion activity versus INTS9 in BLOOD_Myeloma (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	INTS9 →	+0.903	+0.386	<.001	.003	2	5
OESOPHAGUS	DNAJC24 →	+1.181	+0.204	<.001	<.001	3	4
BLOOD_Leukemia	SEPTIN9 →	-1.701	-0.863	.003	.004	3	4
LUNG_SCLC	TNFRSF1A →	-1.498	-0.661	.003	.003	3	4
PANCREAS	CCDC88C →	-1.760	-1.452	.004	.001	3	3
PANCREAS	PTPRK →	-2.215	-1.432	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014048 vs INTS9 — BLOOD_Myeloma

Explore this scatter interactively →