Glutamate secretion

Across TCGA patient cohorts, RNA activity of the Glutamate secretion pathway is significantly associated with the RNA expression of multiple genes, with the LGG cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNCA, KLHL5, and ABCC9, each associated with the pathway in up to 24 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamate secretion activity versus SNCA in LGG (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LGG	SNCA →	+1.278	+0.038	<.001	<.001	3	24
SARC	KLHL5 →	+0.792	+0.034	<.001	<.001	3	19
STAD	ABCC9 →	+1.116	+0.043	<.001	<.001	3	19
CHOL	CCSER2 →	+0.807	+0.030	.001	.006	2	19
DLBC	ARSB →	+0.819	+0.038	<.001	<.001	2	19
THYM	RECK →	+1.141	+0.039	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014047 vs SNCA — LGG

Explore this scatter interactively →