Glutamate secretion

Across TCGA patient cohorts, RNA activity of the Glutamate secretion pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GJA1, H2AC16, and E2F2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamate secretion activity versus GJA1 in HNSC (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GJA1 →	+1.097	+0.675	<.001	<.001	3	5
UCEC	H2AC16 →	-1.604	-0.686	<.001	<.001	3	5
GBM	E2F2 →	-0.794	-0.703	.004	.001	3	5
UCEC	E2F1 →	-1.032	-0.935	<.001	<.001	3	5
BRCA	FOXM1 →	-1.021	-0.637	.003	.003	3	5
BRCA	FBXO5 →	-0.716	-0.683	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014047 vs GJA1 — HNSC

Explore this scatter interactively →