Dopamine secretion

pathway activity — cross-omics
GO:0014046Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Dopamine secretion pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ABAT, RPS3, and RRM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
BRCAABAT →+1.032+0.056<.001<.00135
COADRPS3 →-0.216-0.026.002.00535
COADRRM1 →-0.414-0.030.003.00335
GBMSNCG →+0.860+0.077<.001<.00135
LSCCSNCG_S124 →+1.010+0.054<.001<.00135
GBMHK2 →-0.288-0.046.008.00535
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration