Schwann cell development

Across TCGA patient cohorts, RNA activity of the Schwann cell development pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CDH5, MAP7D2, and SIPA1L3_S158, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Schwann cell development activity versus CDH5 in PDAC (Pearson r = -0.08).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CDH5 →	-0.208	-0.024	.002	.004	3	5
COAD	MAP7D2 →	+1.581	+0.070	.005	.003	3	4
LSCC	SIPA1L3_S158 →	+0.451	+0.039	.002	.001	3	4
LSCC	CDK5 →	+0.269	+0.054	<.001	<.001	3	4
CCRCC	ELK3_S396 →	-0.488	-0.069	.001	<.001	3	4
LSCC	MAP1A_S1600 →	+1.551	+0.079	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014044 vs CDH5 — PDAC

Explore this scatter interactively →