Schwann cell development

Across TCGA patient cohorts, RNA activity of the Schwann cell development pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TGFBI, TMBIM1, and MYOF, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Schwann cell development activity versus TGFBI in HNSC (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TGFBI →	+1.530	+0.220	<.001	<.001	3	5
UCEC	TMBIM1 →	+0.574	+0.241	.003	.004	3	5
LSCC	MYOF →	+0.616	+0.606	.002	.001	2	6
HNSC	PRSS23 →	+0.810	+0.210	<.001	.001	3	5
HNSC	GJA1 →	+1.335	+0.239	<.001	<.001	3	5
LSCC	CD109 →	+0.854	+0.733	.004	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014044 vs TGFBI — HNSC

Explore this scatter interactively →