Schwann cell development

Across TCGA cell cohorts, RNA activity of the Schwann cell development pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CORT, MGLL, and RAB40AL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CORT grouped by Schwann cell development-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CORT →	-0.457	-0.263	.005	<.001	3	4
SKIN	MGLL →	+1.917	+0.815	.008	.002	3	3
CNS	RAB40AL →	+0.181	+0.488	.002	.006	3	3
LIVER	RANGRF →	-0.586	-0.304	.009	.003	2	4
LARGE_INTESTINE	KCNAB3 →	-1.058	-0.223	.001	.008	3	3
BLOOD_Leukemia	DMXL2 →	-1.656	-0.617	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CORT by Schwann cell development activity — PANCREAS

Explore this box plot interactively →