Schwann cell development

Across TCGA cell cohorts, RNA activity of the Schwann cell development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRKCD, CTF1, and TNFSF9, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Schwann cell development activity versus PRKCD in BLOOD_Lymphoma (Pearson r = 0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	PRKCD →	+1.199	+0.277	<.001	.001	3	4
PANCREAS	CTF1 →	-0.934	-0.134	.003	.004	3	4
BLOOD_Lymphoma	TNFSF9 →	+1.722	+0.264	.007	<.001	3	4
BLOOD_Lymphoma	THSD1 →	-1.140	-0.310	<.001	<.001	3	4
BLOOD_Lymphoma	IFI16 →	-2.115	-0.291	<.001	<.001	3	4
CNS	FOSL1 →	+1.631	+0.206	.007	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014044 vs PRKCD — BLOOD_Lymphoma

Explore this scatter interactively →