Schwann cell differentiation

Across TCGA patient cohorts, RNA activity of the Schwann cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP1B_S1965, MAP1B_S614, and THEM6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Schwann cell differentiation activity versus MAP1B_S1965 in LSCC (Pearson r = -0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP1B_S1965 →	+0.787	+0.046	.002	.001	3	7
LUAD	MAP1B_S614 →	+1.196	+0.042	.005	.001	3	5
CCRCC	THEM6 →	-0.319	-0.044	<.001	.003	3	4
OV	TUBB6 →	+0.433	+0.063	<.001	<.001	3	4
CCRCC	EPB41L2_S598 →	+0.744	+0.034	<.001	.008	3	4
UCEC	MAP1B_S1298 →	+0.714	+0.056	.001	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014037 vs MAP1B_S1965 — LSCC

Explore this scatter interactively →