Schwann cell differentiation

Across TCGA patient cohorts, RNA activity of the Schwann cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are S100A10, MYOF, and KLF15, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Schwann cell differentiation activity versus S100A10 in HNSC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	S100A10 →	+1.002	+0.193	<.001	<.001	3	5
PDAC	MYOF →	+0.587	+0.339	<.001	<.001	3	5
HNSC	KLF15 →	-0.912	-0.187	<.001	.001	3	5
PDAC	GJB2 →	+1.223	+0.406	<.001	<.001	3	5
PDAC	RIC3 →	-0.677	-0.281	<.001	.001	3	5
LSCC	ITGB4 →	+1.066	+0.509	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014037 vs S100A10 — HNSC

Explore this scatter interactively →