Schwann cell differentiation

Across TCGA cell cohorts, RNA activity of the Schwann cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAD2L2, RAB40AL, and SRRM3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAD2L2 grouped by Schwann cell differentiation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MAD2L2 →	-1.226	-0.266	<.001	.003	3	3
CNS	RAB40AL →	+0.293	+0.715	<.001	.005	3	3
CNS	SRRM3 →	-1.247	-0.729	.004	.002	3	3
BLOOD_Leukemia	CTTN →	+1.857	+0.731	<.001	.001	3	3
LUNG_NSCLC_LUSC	UGDH →	+1.994	+0.346	.005	.007	2	4
LUNG_NSCLC_LUSC	RADIL →	-1.478	-0.370	.006	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAD2L2 by Schwann cell differentiation activity — PANCREAS

Explore this box plot interactively →