Neural crest cell differentiation

Across TCGA cell cohorts, RNA activity of the Neural crest cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DLGAP4, RHOV, and IGFBP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neural crest cell differentiation activity versus DLGAP4 in URINARY_TRACT (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DLGAP4 →	+0.859	+0.367	<.001	<.001	3	5
URINARY_TRACT	RHOV →	-2.945	-0.307	.001	.002	3	4
URINARY_TRACT	IGFBP2 →	-3.611	-0.355	.001	<.001	3	4
URINARY_TRACT	GJB6 →	-4.638	-0.372	<.001	.002	3	4
URINARY_TRACT	FAM126A →	+1.471	+0.330	<.001	<.001	3	4
URINARY_TRACT	RRAS2 →	+1.398	+0.367	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014033 vs DLGAP4 — URINARY_TRACT

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