Mesenchymal cell development

Across TCGA patient cohorts, RNA activity of the Mesenchymal cell development pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCOLCE, TPM1, and CLEC11A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal cell development activity versus PCOLCE in OV (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PCOLCE →	+0.778	+0.079	<.001	<.001	3	9
UCEC	TPM1 →	+0.686	+0.123	.001	.001	3	9
BRCA	CLEC11A →	+0.682	+0.051	.003	.003	3	9
GBM	COL3A1 →	+0.850	+0.067	<.001	<.001	3	9
CCRCC	LAMB1 →	+0.518	+0.132	<.001	<.001	3	9
UCEC	OLFML3 →	+0.814	+0.114	.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014031 vs PCOLCE — OV

Explore this scatter interactively →