Mesenchymal cell development

Across TCGA patient cohorts, RNA activity of the Mesenchymal cell development pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PGBD5, LINC01315, and GPC6-AS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Mesenchymal cell development activity versus PGBD5 in UCEC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGBD5 →	+1.061	+0.265	<.001	<.001	3	4
HNSC	LINC01315 →	+0.597	+0.134	.004	.008	3	3
CCRCC	GPC6-AS2 →	+0.587	+0.136	.004	<.001	3	3
OV	TUBGCP2 →	+0.354	+0.245	<.001	<.001	3	3
OV	GPR35 →	+0.823	+0.199	.009	.006	3	3
OV	SHC4 →	+0.199	+0.139	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014031 vs PGBD5 — UCEC

Explore this scatter interactively →