Mesenchymal cell development

Across TCGA cell cohorts, RNA activity of the Mesenchymal cell development pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX12, MKRN3, and NDRG1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SNX12 grouped by Mesenchymal cell development-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SNX12 →	+0.925	+1.636	<.001	.004	3	5
BLOOD_Myeloma	MKRN3 →	+3.277	+1.497	.006	.008	2	4
KIDNEY	NDRG1 →	-2.798	-1.429	.003	.005	2	4
KIDNEY	RAB19 →	+0.907	+1.096	.007	.003	3	3
KIDNEY	SLX4IP →	+0.852	+1.082	<.001	.003	3	3
BREAST	VIRMA →	-0.824	-0.926	.003	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SNX12 by Mesenchymal cell development activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →