Neuroblast differentiation

Across TCGA patient cohorts, RNA activity of the Neuroblast differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NOTCH3, LRP5, and PSMA2, each associated with the pathway in up to 21 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuroblast differentiation activity versus NOTCH3 in LAML (Pearson r = 0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	NOTCH3 →	+1.995	+1.422	<.001	<.001	3	21
TGCT	LRP5 →	+0.716	+0.076	<.001	<.001	3	16
UVM	PSMA2 →	-1.034	-0.130	<.001	<.001	3	14
UVM	WASHC3 →	-0.670	-0.075	<.001	.001	2	15
GBM	SRPX →	-1.014	-0.076	<.001	<.001	2	15
LGG	DLX1 →	-1.056	-0.111	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014016 vs NOTCH3 — LAML

Explore this scatter interactively →