Neuroblast differentiation

Across TCGA patient cohorts, RNA activity of the Neuroblast differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PCIF1_S116, PAK1_S144, and U2SURP_S485, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neuroblast differentiation activity versus PCIF1_S116 in HNSC (Pearson r = -0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PCIF1_S116 →	-0.317	-0.152	.005	.003	3	5
LSCC	PAK1_S144 →	-0.495	-0.098	.001	.001	3	5
LUAD	U2SURP_S485 →	+0.602	+0.091	.001	.007	3	5
UCEC	ATP1A1_Y260 →	-0.646	-0.208	.002	<.001	3	4
CCRCC	CSPG4 →	+0.424	+0.140	<.001	<.001	3	4
LUAD	DENND1B_S590 →	-0.883	-0.258	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014016 vs PCIF1_S116 — HNSC

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