Positive regulation of gliogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of gliogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MITD1, BOLA3, and TRAF3IP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MITD1 grouped by Positive regulation of gliogenesis-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	MITD1 →	+0.575	+0.297	.001	<.001	3	5
OVARY	BOLA3 →	+0.656	+0.887	<.001	.001	3	4
SKIN	TRAF3IP1 →	+0.497	+0.186	.006	.002	2	4
LUNG_SCLC	SRSF9 →	+0.526	+0.293	.001	.005	3	3
LUNG_SCLC	CAMK2G →	+0.811	+0.282	.008	<.001	3	3
LUNG_SCLC	AGGF1 →	+0.614	+0.246	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MITD1 by Positive regulation of gliogenesis activity — LUNG_SCLC

Explore this box plot interactively →