Positive regulation of gliogenesis

Across TCGA cell cohorts, RNA activity of the Positive regulation of gliogenesis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHOA, MED12L, and MYRF, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of gliogenesis activity versus RHOA in LIVER (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	RHOA →	+0.589	+0.290	<.001	<.001	3	4
SOFT_TISSUE	MED12L →	+1.092	+0.378	.008	.005	3	3
STOMACH	MYRF →	-2.990	-1.342	.001	.006	3	3
SOFT_TISSUE	TCN2 →	-2.432	-0.329	<.001	<.001	3	3
SOFT_TISSUE	CTSH →	-2.329	-0.346	.004	.005	3	2
SOFT_TISSUE	SGK3 →	-1.608	-0.351	.009	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014015 vs RHOA — LIVER

Explore this scatter interactively →