Peripheral nervous system axon regeneration

Across TCGA cell cohorts, RNA activity of the Peripheral nervous system axon regeneration pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TSPO, APOA4, and MMP2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TSPO grouped by Peripheral nervous system axon regeneration-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TSPO →	-0.501	-1.626	<.001	<.001	3	8
LARGE_INTESTINE	APOA4 →	-0.288	-1.791	<.001	<.001	3	6
STOMACH	MMP2 →	-0.271	-1.360	.002	.004	3	6
BREAST	NEFL →	-0.224	-0.747	<.001	.002	3	6
LUNG_SCLC	SGK3 →	-0.216	-0.982	.009	.001	3	6
SOFT_TISSUE	CDK2AP1 →	-0.335	-1.188	.002	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TSPO by Peripheral nervous system axon regeneration activity — CNS

Explore this box plot interactively →