Schwann cell proliferation

pathway activity — cross-omics
GO:0014010Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Schwann cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ALDH4A1, CD247, and ZNF101, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMALDH4A1 →+0.524+0.193.005.00134
LUADCD247 →-0.488-0.773.001<.00134
GBMZNF101 →-0.297-0.245.001.00134
HNSCLYL1 →-0.596-0.266.003.00933
CCRCCINKA1 →-0.700-0.688.002.00333
BRCAHSPA12B →-0.512-0.184.001.00824
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration