Glial cell proliferation

Across TCGA patient cohorts, RNA activity of the Glial cell proliferation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are F13A1, COL6A3, and RSU1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell proliferation activity versus F13A1 in CCRCC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	F13A1 →	+0.598	+0.046	<.001	<.001	3	8
LSCC	COL6A3 →	+0.371	+0.047	<.001	<.001	3	7
UCEC	RSU1 →	+0.407	+0.055	.001	.009	3	7
BRCA	SELL →	+0.447	+0.025	<.001	<.001	3	7
BRCA	SERPING1 →	+0.635	+0.041	<.001	<.001	3	7
LSCC	SP100_S171 →	+0.598	+0.056	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014009 vs F13A1 — CCRCC

Explore this scatter interactively →