Glial cell proliferation

Across TCGA patient cohorts, RNA activity of the Glial cell proliferation pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDC42EP3, RNU7-151P, and PLEK2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glial cell proliferation activity versus CDC42EP3 in COAD (Pearson r = -0.11).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CDC42EP3 →	-0.519	-0.640	<.001	.002	3	4
GBM	RNU7-151P →	+1.317	+0.196	<.001	<.001	3	4
PDAC	PLEK2 →	-0.547	-0.713	.001	<.001	3	4
OV	KANSL1-AS1 →	+0.597	+0.285	.004	.001	3	3
UCEC	TP53INP1 →	+0.281	+0.513	.008	.001	3	3
PDAC	TMEM127 →	-0.248	-0.509	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014009 vs CDC42EP3 — COAD

Explore this scatter interactively →