Oligodendrocyte development

Across TCGA patient cohorts, RNA activity of the Oligodendrocyte development pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPPP, TCEAL6, and ZDHHC11B, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Oligodendrocyte development activity versus TPPP in GBM (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TPPP →	+1.207	+0.287	<.001	<.001	3	4
GBM	TCEAL6 →	+0.811	+0.236	.004	<.001	3	4
LSCC	ZDHHC11B →	+1.276	+0.231	<.001	<.001	3	4
GBM	GLT1D1 →	+0.802	+0.273	<.001	<.001	3	3
OV	PLN →	+1.110	+0.202	.005	.001	3	3
PDAC	NBPF3 →	-0.367	-0.235	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014003 vs TPPP — GBM

Explore this scatter interactively →