Oligodendrocyte development

Across TCGA cell cohorts, RNA activity of the Oligodendrocyte development pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEN1, MOSPD3, and PRDX5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MEN1 grouped by Oligodendrocyte development-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	MEN1 →	-1.003	-0.490	.004	.001	3	5
BLOOD_Myeloma	MOSPD3 →	-0.803	-0.409	<.001	.002	3	4
BLOOD_Myeloma	PRDX5 →	-0.923	-0.486	.001	<.001	3	4
CNS	TAF10 →	-0.993	-0.273	<.001	<.001	3	4
CNS	CACTIN →	-0.438	-0.277	.001	.001	3	4
CNS	MAPKAPK2 →	-0.787	-0.314	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MEN1 by Oligodendrocyte development activity — BLOOD_Myeloma

Explore this box plot interactively →