Astrocyte development

Across TCGA patient cohorts, RNA activity of the Astrocyte development pathway is significantly associated with the RNA expression of multiple genes, with the LAML cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB3, LILRA1, and C5AR1, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Astrocyte development activity versus LILRB3 in LAML (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LAML	LILRB3 →	+2.182	+0.107	<.001	<.001	3	32
LAML	LILRA1 →	+2.131	+0.091	<.001	<.001	3	31
LAML	C5AR1 →	+3.385	+0.123	<.001	<.001	3	31
LAML	SIGLEC9 →	+2.713	+0.113	<.001	<.001	3	30
DLBC	FPR2 →	+2.498	+0.086	<.001	<.001	3	30
LAML	FPR1 →	+3.119	+0.114	<.001	<.001	3	30

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014002 vs LILRB3 — LAML

Explore this scatter interactively →