Astrocyte development

Across TCGA patient cohorts, RNA activity of the Astrocyte development pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HCK, ITGAM, and RETN, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Astrocyte development activity versus HCK in GBM (Pearson r = 0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	HCK →	+0.438	+0.050	<.001	<.001	3	9
GBM	ITGAM →	+0.716	+0.070	<.001	<.001	3	9
OV	RETN →	+0.892	+0.044	.002	.005	3	8
OV	SKAP2 →	+0.658	+0.065	<.001	<.001	3	8
UCEC	SNX17 →	+0.182	+0.049	<.001	<.001	3	8
BRCA	TBC1D2B →	+0.326	+0.049	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014002 vs HCK — GBM

Explore this scatter interactively →