Astrocyte development

Across TCGA patient cohorts, RNA activity of the Astrocyte development pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPARC, VIM, and COL5A1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Astrocyte development activity versus SPARC in OV (Pearson r = -0.05).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SPARC →	+1.053	+0.195	<.001	<.001	3	9
OV	VIM →	+1.135	+0.364	<.001	<.001	3	9
OV	COL5A1 →	+1.315	+0.209	<.001	<.001	3	9
OV	COL6A3 →	+1.302	+0.220	<.001	<.001	3	9
OV	SERPINE1 →	+1.356	+0.260	<.001	<.001	3	8
OV	AEBP1 →	+1.394	+0.241	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0014002 vs SPARC — OV

Explore this scatter interactively →